… Progress in both areas should advance preclinical assays of novel therapeutics. In that
regard, more progress in establishing patient-derived spheroid, organoid, and xenograft models …

… To this point, this review has focused on molecular alterations more common … pancreatic
neuroendocrine tumors. It should be noted that poorly differentiated pancreatic neuroendocrine …

… process may help to identify novel therapies to improve treatment outcomes. We present
a complementary bioinformatics approach to identify novel therapies for pNETs. A previous …

… , overexpress this marker (65) and gastrinomas of the pancreas show low expression …
pancreatic marker. Nuclear positivity for PR has been reported in most pancreatic endocrine tumors…

… An interesting recent work by Xue and colleagues carried out on 163 resected pancreatic
neuroendocrine tumors establishes the hepatoid variant as one of the most aggressive group …

… There is also hope that the insights gained from such molecular studies may suggest novel
therapeutic approaches, which are also urgently required for PanNEN patients, especially in …

… Integration of high-grade components and molecular markers successfully led to
categorization of 19 out of 20 ambiguous cases [29]. This example highlights the vital need for the …

… Though a number of therapeutics are currently approved for the treatment for patients with
… Herein we describe novel therapeutics being developed for the treatment of advanced well-…

… pancreatic carcinoma, genetics, and tumor biology has highlighted the role of novel therapeutic
strategies… However, despite recent advances in the management of pancreatic carcinoma…

… tumors. Great progress has been achieved in drug therapy and the combination with local
… strategies for the management of neuroendocrine tumor associated with liver metastases. …